Crosslinked polyalkyleneimine hydrogels with tunable degradation rates

摘要

One aspect of the present invention relates to methods of sealing a wound or tissue plane or filling a void space, or securing meshes, films or other devices within the body. In certain embodiments, the wound is an ophthalmic, pleural or dural wound, or a hernia repair mesh. Remarkably, disclosed herein is the discovery that the use of certain crosslinkers in combination with polyalkyleneimines at specific concentrations can result in hydrogels with tunable degradation properties.

主权项

1. A method of sealing a wound of a patient, comprising the steps of:
combining effective amounts of an activated polyethylene glycol diacid derivative and a covalent crosslinking agent to form a polymeric composition; and applying said polymeric composition to a wound of a patient; wherein the covalent crosslinking agent is polyethyleneimine having a weight average molecular weight of about 400 to about 2000 Daltons; the molar ratio of activated esters on the polyethylene glycol diacid derivative to primary amines on the polyethyleneimine is within a range of about 0.5:1 to about 1.5:1; and the activated polyethylene glycol diacid derivative is represented by formula I: wherein, independently for each occurrence, R is H; m is 5 to 10 inclusive; and w is 20 to 120 inclusive.