MONOCLONAL ANTIBODIES AGAINST ANTITHROMBIN BETA COMPLEXED WITH HEPARIN

摘要

This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin ß complexed with heparin and/or heparin-like structure (??ß?). These ??ß? binding proteins can block the anti-coagulant activity of ??ß to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.