METHODS OF PROGNOSIS AND DIAGNOSIS OF PANCREATIC CANCER

摘要

Disclosed herein are methods of diagnosing pancreatic cancer in a patient by detecting the presence and/or amount of at least three biomarkers of pancreatic cancer in a sample from the patient. The methods and biomarkers may be used to develop an accurate prognosis for a patient having cancer or suspected of having pancreatic cancer, or to accurately diagnose a patient having, or suspected of having pancreatic cancer. The methods and biomarkers may be used to identify and/or classify a patient as a candidate for a cancer therapy.

主权项

1. A method for identifying and treating a subject having or at risk of having pancreatic cancer, the method comprising the steps of:
(a) obtaining a biological sample from the subject; (b) determining the levels of carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 125 (CA125), and CUB and zona pellucida-like domains 1 (CUZD1) in the biological sample from the subject; (c) comparing the levels of CA19-9, CA125, and CUZD1 in the biological sample to reference levels of CA19-9, CA125, and CUZD1; (d) identifying the subject as having pancreatic cancer or at risk of having pancreatic cancer if the levels of CA19-9, CA125, and CUZD1 in the biological sample are greater than the reference levels of CA19-9, CA125, and CUZD1; and (e) administering a therapy against pancreatic cancer to the subject identified as having pancreatic cancer or a means by which to monitor pancreatic status in said subject identified as at risk of having pancreatic cancer.