Process for Preparing Quinoline Derivatives

摘要

A process for preparing a compound of Formula I is disclosed, comprising the steps:;;wherein:
R1 is halo;R2 is halo;R3 is (C1-C6)alkyl or (C1-C6)alkyl optionally substituted with heterocycloalkyl;R4 is (C1-C6)alkyl; andQ is CH or N;

comprising:
(a) contacting 1,1-cyclopropane dicarboxylic acid with thionyl chloride in a polar aprotic solvent;(b) adding;;and a tertiary amine base to the mixture of step (a) to form a compound of Formula A; and;(c) coupling a compound of Formula A with an amine of Formula B to form a compound of Formula I.;

主权项

1. A processes for preparing a compound of Formula A: wherein R2 is H, F, Cl, or Br;comprising
(a) contacting 1,1-cyclopropane dicarboxylic acid with thionyl chloride in a polar aprotic solvent; and (b) addingand a tertiary amine base to mixture of step (a).