PHARMACEUTICAL COMPOSITION BASED ON EPIGALLOCATECHIN GALLATE-CONTAINING NANO-MICELLES AND USE THEREOF TO TREAT ATOPIC DERMATITIS, CROHN'S DISEASE, ADENOMYOSIS AND HYPERPLASTIC PROSTATE DISORDERS

摘要

The invention relates to pharmacy. It is an object of the present invention to produce nanomicellar structures containing EGCG and achieving a positive result consisting in increasing bioavailability in peroral administration. The object of this invention is achieved by a new pharmaceutical composition for peroral administration containing epigallocatechin-3-gallate as the active component and a target additive that is a block copolymer of oxyethylene and oxypropylene, in which the content of the hydrophobic block is less than 50% by mass and the hydrophilic block has a molecular weight of 2,250 daltons or more at a ratio of the active component to the block copolymer ranging from 1:1 to 10:1. The composition improves absorption of the active compound by the blood flow when delivered perorally.