Cell growth-promoting peptide and use thereof

摘要

The pharmaceutical composition includes at least one pharmaceutically acceptable carrier, and an active ingredient including an artificially synthesized peptide includes: (A) an amino acid sequence constituting a cell-penetrating peptide and (B) an amino acid sequence constituting the signal peptide in amyloid precursor protein (APP) or an N-terminal partial amino acid sequence or C-terminal partial amino acid sequence from the amino acid sequence constituting that signal peptide.

主权项

1. A method of producing mesenchymal stem cells in an undifferentiated state originating from a human or from a non-human mammal, the method comprising:
preparing an artificially synthesized peptide for promoting proliferation of at least one kind of mesenchymal stem cell in an undifferentiated state; and supplying the synthesized peptide at least once to the mesenchymal stem cell subjected to proliferation; wherein: the artificially synthesized peptide comprises: (A) an amino acid sequence consisting of SEQ ID NO: 14; and (B) an amino acid sequence consisting of SEQ ID NO: 20, or an N-terminal partial amino acid sequence of SEQ ID NO: 20, or a C-terminal partial amino acid sequence of SEQ ID NO: 20, wherein: the N-terminal partial amino acid sequence consists of five or more consecutive amino acid residues counting from the N-terminal amino acid residue of the amino acid sequence of SEQ ID NO: 20, and the C-terminal partial amino acid sequence consists of five or more consecutive amino acid residues counting from the C-terminal amino acid residue of the amino acid sequence of SEQ ID NO: 20.