Modulation Of The VPS10p-Domain Receptor Family For The Treatment Of Mental And Behavioural Disorders

摘要

The present invention relates to methods for modulating the activity of one or more Vps10p-domain receptors selected from the group consisting of Sortilin, SorLA, SorCS1, SorCS2 and SorCS3, in an animal and methods for preparation of a medicament for the treatment of mental and behavioral disorders. The modulation is carried out by inhibiting or promoting the binding of ligands to the Vps10p-domain receptor. In vitro and in vivo methods for screening for agents capable of modulation of said Vps10p-domain receptor activity are also provided. The invention furthermore relates to methods of altering expression of said receptors in vivo.

主权项

1. A method for treating a bipolar disorder in an individual in need thereof, said method comprising administering to said individual, a therapeutically effective amount of a sortilin-related Vps10p domain-containing receptor 2 (SorCS2) modulator or a Sortilin modulator, wherein:
(A) the SorCS2 modulator is an anti-SorCS2 polyclonal antibody or a fragment thereof which binds to SorCS2, or is an anti-SorCS2 monoclonal antibody or a fragment thereof which binds to SorCS2; and (B) the Sortilin modulator is an anti-Sortilin polyclonal antibody or a fragment thereof which binds to Sortilin, or is an anti-Sortilin monoclonal antibody or a fragment thereof which binds to Sortilin.