Tissue disorder imaging analysis

摘要

Methods and systems are described for quantitatively determining a score for a patient having a disorder, e.g., a stroke, in a tissue, such as the brain, by analyzing both the extent and location of damage to the tissue caused by the disorder.

主权项

1. A system for determining a hazard score for a patient having a disorder in a patient tissue, comprising a device arranged to obtain or store an image of the patient's tissue, wherein the image comprises a plurality of patient image voxels; a memory or computer-readable medium storing a non-patient specific hazard atlas of a disorder in a tissue, wherein the hazard atlas comprises a plurality of voxels, each voxel representing a hazard value of an extent of deficit caused by damage from the disorder to that voxel of the tissue at that location, such that the hazard value contains location specific information about the impact that the voxel's death would have on behavior; an output device; and a processor linked to the imaging device, memory, and output device, wherein the processor is programmed to (i) obtain the image of the patient's tissue; (ii) identify voxels of the patient image that are damaged by the disorder as damaged patient image voxels; (iii) obtain from the memory or computer-readable medium the hazard atlas of the disorder in the tissue; (iv) compute a hazard score for the patient, wherein the score is the integration of all damaged patient image voxels weighted by the hazard value corresponding to that voxel location; and (v) transmit the hazard score to the output device.