发明名称 |
Virus-like particles comprising chimeric human immunodeficiency virus (HIV)/mouse mammary tumor virus (MMTV) envelopes |
摘要 |
Embodiments of the present disclosure encompasses virus-like particles, methods of making virus-like particles, including expression vectors, wherein the virus-like particles may comprise enhanced levels of capsid-bound a chimeric HN-Env polypeptide compared to VLPs derived from unmodified HIV-env polypeptides. Embodiments of the virus-like particle may have Env-specific epitopes exposed on the outer surface thereof. In one embodiment, the Env-specific epitopes exposed on the outer surface of the virus-like particle may specifically bind with an anti-HIV-Env specific antibody. Embodiments of the disclosure further includes methods of generating an antibody specific to an epitope of an HIV-Env polypeptide, comprising delivering to an animal or a human an effective amount of a suspension of virus-like particles comprising a chimeric HIV-Eny polypeptide, thereby inducing the formation of an antibody specific to an epitope of an HIV-1 eny polypeptide. |
申请公布号 |
US8795682(B2) |
申请公布日期 |
2014.08.05 |
申请号 |
US200812598271 |
申请日期 |
2008.05.02 |
申请人 |
Emory University;The UAB Research Foundation;Novavax, Inc. |
发明人 |
Compans Richard W.;Wang Baozhong;Hahn Beatrice;Liu Weimin;Smith Gale;Pushko Peter |
分类号 |
A61K39/12;A61K39/21 |
主分类号 |
A61K39/12 |
代理机构 |
Emory Patent Group |
代理人 |
Emory Patent Group |
主权项 |
1. A virus-like particle comprising a chimeric human immunodeficiency virus (HIV)-Env polypeptide comprising a mouse mammary tumor virus (MMTV) transmembrane domain and cytoplasmic tail. |
地址 |
Atlanta GA US |