Peptides for inhibiting chemokine binding to chemokine receptors

摘要

Novel peptidic or peptidomimetic agents or small molecules for modulating the biological effect of a chemokine. According to the present invention, the therapeutic agents preferably are endowed with the capacity to bind to certain chemokines in order to modulate the biological interaction between the target ligand, chemokine, and the respective target receptor, chemokine receptor. These peptides may be described as agonist ligands or antagonists. Next, preferably certain peptides share consensus sequences are described which characterize the families or categories of these modulator peptides.

主权项

1. A method of inhibiting the binding of a chemokine to a chemokine receptor, wherein said chemokine is selected from the group consisting of MCP-1 (monocyte chemotactic protein-1), MIG (monokine induced by gamma interferon), eotaxin and IL-8 (interleukin 8), the method comprising contacting the chemokine with an effective amount of a peptidic chemokine modulator comprising a peptide comprising the amino acid sequence of SEQ ID NO: 101.