Complex of amorphous tomoxiprole and cyclodextrin with fast dissolution rate and process for the preparation thereof

摘要

A stable complex of tomoxiprole with 2-hydroxypropyl-beta-cyclodextrin with fast dissolution rate and rapid absorption wherein amorphous tomoxiprole forms a complex with 2-hydroxypropyl-beta-cyclodextrin in about equimolecular ratio. The complex shows a remarkably faster dissolution rate and absorption with respect to crystalline tomoxiprole and is particularly suitable for the production of pharmaceutical oral dosage forms, such as tablets and capsules, where rapid onset of therapeutical action is required. A method of manufacture of the complex is also described and claimed.

主权项

1. A complex of tomoxiprole with 2-hydroxypropyl-beta-cyclodextrin wherein tomoxiprole is stabilized in amorphous form and the molar ratio between the amorphous tomoxiprole and 2-hydroxypropyl-beta-cyclodextrin ranges from 0.9:1 and 1:1.