| 摘要 |
2,4-Diaminopyrimidine derivatives (I) are used as fungicides. 2,4-Diaminopyrimidine derivatives of formula (I) are used as fungicides. X 1>N or CR 3>; X 2>N or CR 4>; A : C(R 14>) 2 or a bond; R 1>-R 5>H, halo, CN, OH, NO 2, heterocyclic or carbocyclic rings, OR, SR, SOR, SO 2R, SONRR, SO 2NRR, OSO 2NRR, COR, NRCOOR', NRCSOR', NRR, NRCOR, NRSO 2R', NRSOR', OCONRR, OCOR, CONRR, COOR, CR 2OR, (CH 2) mQ, optionally substituted 1-8C alkyl, 1-8C haloalkyl or 3-8C cycloalkyl, or two of R 2>-R 4> can form a ring; m : 1-8; Q : CR 2OR, OR, SR, SOR, SO 2R, SONRR, SO 2NRR, NRR, COOR, COR, NRCOR or NRCOOR; R 6>H; benzyl, 1-8C alkyl, 1-4C alkylcarbonyl, (1-4C)alkoxy(1-4C)alkyl, 2-6C alkenyl or 2-6C alkynyl, all optionally substituted; 1-4C alkoxycarbonyl, 1-6C alkylsulfinyl, 1-6C alkylsulfonyl, 3-8C cycloalkyl, 1-6C haloalkyl, 1-4C haloalkylsulfinyl, 1-4C haloalkylsulfonyl, haloalkoxyalkyl, halocycloalkyl, CHO, formyl(1-3C)alkyl, alkanoylalkyl, alkoxycarbonylalkyl, haloalkanoylalkyl, haloalkoxycarbonyl, 1-8C alkylcarbonyl, 1-8C alkoxycarbonyl, 1-8C alkylthiocarbonyl, alkoxyalkanoyl, alkenyloxycarbonyl, alkynyloxycarbonyl, 3-8C cycloalkylcarbonyl 1-6C haloalkylcarbonyl, 1-6C haloalkylthiocarbonyl, 1-6C haloalkoxycarbonyl, 3-6C haloalkenyloxycarbonyl, 3-6C haloalkynyloxycarbonyl, haloalkoxyalkanoyl, halocycloalkylcarbonyl, CH 2CCR 1>', CH 2CH=CHR 1>', CH=C=CHR 1>', COCOR 2>, CONR 3>R 4>, CH 2NR 5>R 6>, trialkylsilyl, trialkylsilylethyl or phenyldialkylsilyl; R 1>' : H, 1-6C alkyl, 1-6C haloalkyl, 2-6C alkenyl, 2-6C alkynyl, 3-7C cycloalkyl, alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl or CN; R 7>H, CN, Me or 1-3C haloalkyl; R 8>halo, CN, Me or 1-3C haloalkyl; R 9>H; 1-8C alkyl, aryl, benzyl, alkoxyalkyl, alkenyl or alkynyl, all optionally substituted; 3-8C cycloalkyl, 1-8C haloalkyl, trialkylsilyl, 1-6C alkylsulfinyl or 1-6C alkylsulfonyl; R 10>H, 1-8C alkoxy, optionally substituted 1-8C alkyl, 3-8C cycloalkyl, 1-8C haloalkyl, trialkylsilyl, optionally substituted aryl, COOR, COR, OR; R 11>H, F, Cl, Br, optionally substituted 1-8C alkyl, 1-8C alkoxy, 3-8C cycloalkyl, 1-8C haloalkyl, trialkylsilyl, optionally substituted aryl or optionally substituted cyclopropyl; R : H, substituted 1-8C alkyl, trialkylsilyl or optionally substituted 1-8C haloalkyl, 3-6C cycloalkyl, 2-6C alkenyl, 3-6C alkynyl, aryl, alkoxyalkyl, benzyl or a 3- to 7-membered ring with 0-4 heteroatoms, or R+R forms a 3- to 7-membered ring with 0-4 other heteroatoms; R' : trialkylsilyl, alkoxyalkyl or optionally substituted 1-8C alkyl, 1-8C haloalkyl, alkenyl, alkynyl, 3-6C cycloalkyl, aryl, benzyl or a 3- to 7-membered ring with 0-4 heteroatoms, or R'+R' forms a 3- to 7-membered ring with 0-4 other heteroatoms. Independent claims are also included for 6 sets of new compounds (I) and their use for controlling unwanted microorganisms. [Image] - ACTIVITY : Plant antifungal. Several compounds (I), e.g. 5-chloro-4-cyclopropylamino-2-(3-chlorophenylamino)pyrimidine, gave more than 70% protection of young apple plants against Venturia inaequalis infection at a concentration of 100 ppm. - MECHANISM OF ACTION : None given. |
