DOWN REGULATION OF THE GENE EXPRESSION BY MEANS OF NUCLEIC ACID-LOADED VIRUS-LIKE PARTICLES

摘要

The present invention relates to compositions of virus-like particles for the introduction of RNA-interference (RNAi-) inducing molecules into eukaryotic cells and methods for the cell type-specific transduction of a plurality of eukaryotic cells with RNAi-inducing molecules. The present invention furthermore relates to methods for a diagnosis, prevention and/or treatment of diseases or disease states associated with an increased expression rate of at least one endogenous gene, and/or with the undesired expression of at least one endogenous gene and/or foreign nucleic acids, in particular viral nucleic acids.

主权项

1. A composition, comprising a virus-like particle (VLP) wherein said VLP comprises at least one viral capsid protein, and wherein at least one RNA-interference (RNAi-) inducing molecule is included in the interior of the VLP.