| 主权项 |
1. A compound, or salt thereof, of formula (I-Z-2): wherein
R1 is pyrazole, imidazol-5-yl, triazolyl, triazolonyl, indoly-2-yl, indol-4-yl, indol-5-yl, indole-6-yl, indol-7-yl, benzimidazolyl, azabenzimidazolyl, azaindolyl, benzothiazolyl or benzoxazolyl, where R1 is optionally substituted with one, two, three, four, or five R6;
each R6 is independently hydroxy, halo, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heteroalkyl optionally substituted heteroalicyclyl, optionally substituted alkylcycloalkyl, optionally substituted alkylheteroalicyclyl, C(O)R, C(O)OR, NR′R″, NR′C(O)R″, NRC(O)NR′R″, NR′S(O)2R″, C(O)NR′R″, S(O)2R, or S(O)2NR′R″;R1a is hydrogen, optionally substituted alkyl, optionally substituted heteroalkyl, optionally substituted cycloalkyl or optionally substituted heteroalicyclyl;each of R2 and R4 is independently hydrogen, hydroxy, halo, haloalkyl, haloalkoxy, alkyl, cycloalkyl, alkoxy, aryl, heteroaryl, or heteroalkyl, C(O)R, C(O)OR, NR′R″, NR′C(O)R″, NRC(O)NR′R″, NR′S(O)2R″, C(O)NR′R″, S(O)2R, or S(O)2NR′R″;R3 is hydroxy, halo, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heteroalkyl, C(O)R, C(O)OR, NR′R″, NR′C(O)R″, NRC(O)NR′R″, NR′S(O)2R″, C(O)NR′R″, S(O)2R, or S(O)2NR′R″;R5 is hydrogen, halo, haloalkyl or alkyl; and
each of R, R′ and R″ are independently hydrogen, alkyl, haloalkyl, cycloalkyl, aryl, heteroaryl, or heteroalkyl; orR′ and R″ taken together with the nitrogen to which they are attached form a ring structure that optionally includes an additional heteroatom selected from N or O and is optionally substituted. |
