主权项 |
1. A compound of formula (I) wherein: R1 is selected from the group consisting of a 5- or 6-membered heteroaromatic ring which contains 1, 2, or 3 heteroatoms independently selected from N, O, and S; and optionally a second ring is condensed to the heteroaromatic ring, wherein the second ring is unsaturated or aromatic and 5- or 6-membered and optionally contains 1, 2, or 3 heteroatoms independently selected from N, O, and S, and 1 or 2 —CH2— groups in the second ring are optionally replaced by —N(RN)—, —C(═O)—, —S(═O)—, or —S(═O)2—, the heteroaromatic ring and/or the second ring the H-atom in one or more NH groups is optionally replaced by RN, each of the heteroaromatic ring and/or the second ring are independently optionally substituted with one or more substituents selected from LA, and the heteroaromatic ring or the second ring are optionally substituted with a group RC; RN is independently H, C1-4-alkyl, C1-4-alkyl-C(═O)—, or C1-4-alkyl-S(═O)2—; A is selected from the group consisting of a 1,2,3,6-tetrahydropyridin-4-yl ring substituted at the N with C1-4-alkyl-S(═O)2—, a phenyl ring, and a 5- or 6-membered heteroaromatic ring which contains 1, 2, or 3 heteroatoms independently selected from N, O, and S, and optionally a second ring is condensed to the phenyl ring or heteroaromatic ring, wherein the second ring is unsaturated or aromatic and 5- or 6-membered and optionally contains 1, 2, or 3 heteroatoms independently selected from N, O, and S, and 1 or 2 —CH2— groups in the second ring are optionally replaced by —N(RN)—, —C(═O)—, —S(═O)—, or —S(═O)2—, the heteroaromatic ring and/or the second ring the H-atom in one or more NH groups are optionally replaced by RN, each of the phenyl ring, heteroaromatic ring, and/or second ring are independently optionally substituted with one or more substituents selected from LA, and the phenyl ring, heteroaromatic ring, or second ring are optionally substituted with a group T; T is selected from the group consisting of F, Cl, Br, I, CN, OH, NO2, C1-6-alkyl-, C1-6-alkenyl-, C1-6-alkynyl-, C3-6-cycloalkyl, C1-6-alkyl-O—, C3-6-cycloalkyl-O—, C1-6-alkyl-S—, HO—C(═O)—, C1-6-alkyl-O—C(═O)—, C1-4-alkyl-C(═O)—, C3-6-cycloalkyl-C(═O)—, C1-4-alkyl-S(═O)—, C1-4-alkyl-S(═O)2—, RNT1RNT2N—, RNT1RNT2N—C(═O)—, RNT1RNT2N—S(═O)2—, RNT1RNT2N—C(═O)—(RN)N—, heterocyclyl, heterocyclyl-O—, aryl, aryl-O—, heteroaryl, and heteroaryl-O—, wherein each alkyl, alkenyl, alkynyl, and cycloalkyl group is optionally substituted with one or more substituents independently selected from F, Cl, CN, OH, C1-3-alkyl, C3-6-cycloalkyl, C1-3-alkyl-O—, RNT1RNT2N—, RNT1RNT2N—C(═O)—, C1-4-alkyl-S(═O)—, C1-4-alkyl-S(═O)2—, RNT1RNT2N—S(═O)2—, aryl, heteroaryl, and heterocyclyl, wherein aryl is phenyl or naphthyl, heteroaryl is a 5- or 6-membered aromatic ring which contains 1, 2, 3, or 4 heteroatoms independently selected from N, O, and S, the H-atom in one or more NH groups is optionally replaced by RN, heterocyclyl is a 4- to 7-membered unsaturated or saturated carbocyclic ring in which 1 or 2 —CH2-groups are independently replaced by NRN, O, —C(═O)—, S, —S(═O)—, or —S(═O)2—, and/or in which a —CH-group is replaced by N, and each aryl, heteroaryl, or heterocyclyl group is optionally substituted with one or more substituents independently selected from LA; RNT1 is selected from the group consisting of H, C1-6-alkyl, C3-6-cycloalkyl, C1-6-alkyl-C(═O)—, C1-6-alkyl-S(═O)2, heterocyclyl, aryl, and heteroaryl, wherein each alkyl and cycloalkyl group is optionally substituted with one or more substituents independently selected from the group consisting of F, OH, CN, C1-4-alkyl, C1-4-alkyl-O—, RN2N, C1-4-alkyl-S(═O)2—, C3-6-cycloalkyl, heterocyclyl, phenyl, and heteroaryl, heterocyclyl is optionally substituted with one or more substituents independently selected from F, C1-4-alkyl, RN2N, OH and C1-4-alkyl-O—, heterocyclyl is a C4-7-cycloalkyl ring in which 1 or 2 —CH2-groups are independently replaced by NRN, O, C(═O), S, S(═O), or S(═O)2, aryl is phenyl or naphthyl, heteroaryl is a 5- or 6-membered aromatic ring which contains 1, 2, or 3 heteroatoms independently selected from N, O, and S, wherein the H-atom in one or more NH groups is optionally replaced by RN; and aryl and heteroaryl are optionally substituted with one or more substituents LA; RNT2 is H or C1-6-alkyl; or RNT1 and RNT2 are linked to form one group RNT1-RNT2— selected from the group consisting of a C3-5-alkylene group, wherein 1 or 2 —CH2-groups are independently replaced by NRN, O, C(═O), S, S(═O), or S(═O)2, optionally substituted with one or more substituents independently selected from F, C1-4-alkyl, (RN)2N, OH, and C1-4-alkyl-O—; LA is F, Cl, Br, CN, OH, NO2, C1-4-alkyl-, C1-4-alkyl-O—, (RN)2N—C(═O), (RN)2N—, or C1-4-alkyl-S(═O)2—, wherein each alkyl group is optionally substituted with one or more substituents independently selected from F, Cl, CN, OH, and C1-3-alkyl-O—; LP is F or C1-3-alkyl optionally substituted with one or more F-atoms; LQ is F or C1-3-alkyl optionally substituted with one or more F-atoms; RC is F, Cl, Br, I, CN, OH, NO2, C1-6-alkyl-, C1-6-alkenyl-, C1-6-alkynyl-, C3-6-cycloalkyl, C1-6-alkyl-O—, C3-6-cycloalkyl-O—, C1-6-alkyl-S—, HO—C(═O)—, C1-6-alkyl-O—C(═O)—, C1-4-alkyl-C(═O)—, C3-6-cycloalkyl-C(═O)—, C1-4-alkyl-S(═O)—, C1-4-alkyl-S(═O)2—, RNT1RNT2N—, RNT1RNT2N—C(═O)—, RNT1RNT2N—S(═O)2—, RNT1RNT2N—C(═O) (RN)N—, heterocyclyl, heterocyclyl-O—, aryl, aryl-O—, heteroaryl, and heteroaryl-O—, wherein each alkyl, alkenyl, alkynyl, and cycloalkyl group is optionally substituted with one or more substituents independently selected from F, Cl, CN, OH, C1-3-alkyl, C3-6-cycloalkyl, C1-3-alkyl-O—, RNT1RNT2N—, RNT1RNT2N—C(═O)—, C1-4-alkyl-S(═O)—, C1-4-alkyl-S(═O)2—, RNT1RNT2N—S(═O)2—, aryl, heteroaryl, and heterocyclyl, aryl is phenyl or naphthyl, heteroaryl is a 5- or 6-membered aromatic ring which contains 1, 2, 3, or 4 heteroatoms independently selected from N, O, and S, wherein the H-atom in one or more NH groups is optionally replaced by RN, heterocyclyl is a 4- to 7-membered unsaturated or saturated carbocyclic ring in which 1 or 2 —CH2— groups are independently replaced by NRN, O, —C(═O)—, S, —S(═O)—, or —S(═O)2—, and/or in which a —CH-group is replaced by N, and each aryl, heteroaryl, or heterocyclyl group is optionally substituted with one or more substituents independently selected from LA; X1, X2, and X3 are independently C(R2) or N, such that 1 or 2 members of the group consisting of X1, X2, and X3 is N; R2 is H, F, Cl, CN, OH, C1-4-alkyl, F2HC, F3C, C1-4-alkyl-O—, F2HC—O—, F3C—O—, or C3-7-cycloalkyl-O—; n is 0, 1, 2, 3, or 4; and m is 0, 1, or 2; or a salt thereof. |