Male contraceptive

摘要

A compound having formula I. R1, R2, R3 and R4 are independently H or lower alkyl. R5 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, heterocycloalkyloxy, arylamino, heteroarylamino, cycloalkylamino, heterocycloalkyl amino, arylthio, heteroarylthio, cycloalkylthio, heterocycloalkylthio, or cyclic olefin, any of which may be substituted or non-substituted; or substituted alkyl, substituted alkyl oxy or substituted alkyl amino wherein the substituent is an aryl, a heteroaryl, a cycloalkyl, a heterocycloalkyl or a cyclic olefin, any of which may be substituted or non-substituted. X is C or N. n and p are independently whole numbers selected from 0, 1 and 2. (CH2)n and (CH2)p may be substituted or non-substituted. Ar1 and Ar2 are independently aryl or heteroaryl groups which may be substituted or non-substituted. Certain specific compounds are excluded.;The compounds can be used in a medicament or a method for the reduction or prevention of the emission of sperm, or for the reduction or prevention of transmission of viral agents transmitted in seminal fluid.;

主权项

1. A method of reducing sperm emission, or reducing transfer of viruses or microbes found in ejaculatory material of a human male comprising administering an effective amount of a compound having formula I wherein R1, R2, R3 and R4 are independently H; R5 is selected from the group of structures consisting of: X is CH or N; n and p are independently whole numbers selected from 0, 1 and 2; (CH2)n and (CH2)p are non-substituted; and Ar1 and Ar2 are phenyl or a pharmaceutically acceptable salt.