| 主权项 |
1. A compound of formula IA wherein: R1 is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrrolopyridinyl, imidazopyridinyl, pyrazolopyridinyl or dihydropyrrolopyridinyl optionally substituted with oxo, wherein each heterocycle is optionally independently substituted with one to three groups selected from Ra, Rb and Rc; R2 is C1-C6 alkyl or C3-6 cycloalkyl optionally substituted with C1-3 alkyl; R3 is H, —OH, halogen, —CN, C1-6 alkoxy, —COOR8, —C(O)NR8R9 or 5-6 membered heteroaryl ring which is optionally substituted with C1-3 alkyl; R4, R5, and R6 are each independently selected from
(a) —H,(b) —OH,(c) halogen,(d) —CN,(e) —CF3,(f) C1-6alkyl optionally substituted with one to three —OH, fluorine, C1-6alkoxyl —N(R8)(R9), or —C(O)N(R8)(R9),(g) C3-6cycloalkyl(h) C1-6alkoxy optionally substituted with one to three —OH, fluorine, —OC1-6alkyl, or —OC3-6cycloalkyl(i) —S(O)nC1-6alkyl,(j) —S(O)2aryl(k) —S(O)2heterocycle(l) —CO2R8,(m) —SCF3,(n′) a5-6 membered heterocyclic ring; R8 and R9 are each independently selected from —H, C1-6alkyl, and 5-6 membered heterocyclic ring; Ra is selected from H, —NH2, —NH(C1-C6)alkyl, —NR10R11, —NH—C(O)C1-C6alkyl, NR11—C(O)C1-C6alkyl, —O(C1-C8)alkyl, —O(C3-C6)cycloalkyl, —S—(C1-C6)alkyl, —S(O)—C1-C6alkyl, —S(O)2—C1-C6alkyl, and —CH2—OH; Rb is selected from —H, —(C1-C6)alkyl, —O—(C1-C6)alkyl, —NH2, —CH2—OH, —C≡N, —CH2NH2 and —C(O)OCH3; Rc is selected from —H, —CH3 and —OH; R10and R11 are each independently selected from —H, C1-6alkyl-5-6 membered heterocyclyl, C1-6alkyl-5-6 membered heteroaryl optionally substituted with halogen and C1-6alkyl-aryl; n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof. |
