| 发明名称 | Non-peptidyl, potent, and selective mu opioid receptor antagonists | ||
| 摘要 | Selective, non-peptide antagonists of the mu opioid receptor (MOR) and methods of their use are provided. The antagonists may be used, for example, to identify MOR agonists in competitive binding assays, and to treat conditions related to addiction in which MOR is involved, e.g. heroin, prescription drug and alcohol addiction. | ||
| 申请公布号 | US8772308(B2) | 申请公布日期 | 2014.07.08 |
| 申请号 | US201013144788 | 申请日期 | 2010.01.15 |
| 申请人 | Virginia Commonwealth University | 发明人 | Zhang Yan;Selley Dana E.;Dewey William |
| 分类号 | A61K31/485;C07D489/08 | 主分类号 | A61K31/485 |
| 代理机构 | Whitham, Curtis, Christofferson & Cook, PC | 代理人 | Whitham, Curtis, Christofferson & Cook, PC |
| 主权项 | 1. A selective, non-peptide MOR antagonist represented by formulawhere Z is selected from the group consisting of an aliphatic moiety, NH, CO, (NHCO)n where n=1-5, (CONH)n where n=1-5, (NHCO)(CH2)n(NHCO), where n=1-5, (NHCO)(CH2)n where n=1-5, (CH2)n(NHCO), where n=1-5, and O, and R is selected from the group consisting of | ||
| 地址 | Richmond VA US | ||