Polymeric membranes with human skin-like permeability properties and uses thereof

摘要

The present invention provides synthetic membranes which are suitable as a human skin substitute for the investigation of transdermal diffusion of candidate pharmaceutical and cosmetic compounds. The membranes according to the present invention exhibit human skin-like permeability properties with respect to the diffusion of a wide range of compounds having widely different physico-chemical properties.

主权项

1. A modified ultrafiltration membrane, wherein the modification comprises treatment of the membrane with a mixture of a fatty acid ester and a polydimethylsiloxane, wherein the modified ultrafiltration membrane comprises human skin-like permeability properties and a pore size of 0.1 microns or smaller than 0.1 microns.