| 发明名称 | Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane | ||
| 摘要 | Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, an intermediate in the synthesis of 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof, comprising step (iii): (iii) reacting 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane with chloroacetonitrile in the presence of an acid, wherein 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane is employed in step (iii) as obtained in the reaction of a methylmagnesium halide with 3,3,5,5-tetramethylcyclohexanone without having been subjected to a purification step. | ||
| 申请公布号 | US8759581(B2) | 申请公布日期 | 2014.06.24 |
| 申请号 | US201013379449 | 申请日期 | 2010.06.28 |
| 申请人 | Merz Pharma GmbH & Co. KGaA | 发明人 | Koller Herbert;Pyerin Michael |
| 分类号 | C07C231/06;C07C211/35 | 主分类号 | C07C231/06 |
| 代理机构 | Hueschen and Sage | 代理人 | Hueschen and Sage |
| 主权项 | 1. A method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane comprising step (iii): (iii) reacting 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane with chloroacetonitrile in the presence of an acid, wherein 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane is reacted in step (iii) as obtained via reaction of a methylmagnesium halide with 3,3,5,5-tetramethylcyclohexanone without having been subjected to a purification step. | ||
| 地址 | Frankfurt am Main DE | ||