发明名称 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF BRAIN CANCERS |
摘要 |
<p>Described herein is an isolated viral particle having a genome that includes open reading frames that encode: Maraba proteins N, P, and L, or variants thereof; as well as Maraba protein M or protein delta 51M, or variants thereof; and a Bahia Grande G protein, a LCMV G protein, or an Ebola G protein. Maraba protein N may have a sequence which includes SEQ ID NO: 1. Maraba protein P may have a sequence which includes SEQ ID NO: 2. Maraba protein L may have a sequence which includes SEQ ID NO: 3. Maraba proteins M and delta 1M may have sequence which include SEQ ID NO: 4 and 5, respectively. Bahia Grande G protein may have a sequence which includes SEQ ID NO: 6. LCMV G protein may have a sequence which includes SEQ ID NO: 7. Ebola G protein may have a sequence which includes SEQ ID NO: 8.</p> |
申请公布号 |
CA2894618(A1) |
申请公布日期 |
2014.06.19 |
申请号 |
CA20122894618 |
申请日期 |
2012.12.12 |
申请人 |
CHILDREN'S HOSPITAL OF EASTERN ONTARIO RESEARCH INSTITUTE INC.;OTTAWA HOSPITAL RESEARCH INSTITUTE |
发明人 |
STOJDL, DAVID;BELL, JOHN CAMERON |
分类号 |
C12N7/01;A61K35/12;A61K35/76;A61P35/00;C07K14/08;C07K14/145;C12N15/40;C12N15/47;C12N15/62;C12N15/86 |
主分类号 |
C12N7/01 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|