| 主权项 |
1. A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein A is selected from A′ is selected from O, S and NR2a; A″ is selected from O and S; Y1 is —(CR2bR2c)m— or —CH═CH—; X is selected from —C(═O)—, —N(R3)—C(═O)—, —C(═O)—N(R3)—, —N(R3)— and —CH2—; Y2 is —(CR4aR4b)n—; m is selected from 0, 1, 2, 3, 4 and 5; n is selected from 0, 1, 2, 3, 4 and 5; wherein when Y1 is —(CR2bR2c)m— and A is not HO—C(═O)—, the sum of m and n is not less than 2 and no more than 5; and wherein when Y1 is —(CR2bR2c)m— and A is HO—C(═O)—, the sum of m and n is not less than 2 and no more than 7; or A-Y1—X— is L is selected from W is CH or N; Z is selected from CH2, O and NR6c; Y3 is selected from —O—(CR6aR6b)—, —(CR6cR6d)—O—, —CH═CH—, —CR6eR6f—CR6gR6h—, and —O—(CR6iR6j—CR6kR6l)—; R1a, R1b, R1c, R1d and R1e are defined according to any one of (a) R1b is halogen; R1d is halogen, CN, C1-4alkyl, C1-4haloalkyl or C1-4haloalkoxy; and R1a, R1c and R1e are H; (b) R1b is halogen; R1d is halogen, CN, C1-4alkyl, C1-4haloalkyl or C1-4haloalkoxy; R1c is halogen; and R1a and R1e are H; (c) R1b is C1-4alkyl; R1d is C1-4alkyl, C1-4haloalkyl, C1-4haloalkoxy or CN; R1a, R1c and R1e are H; (d) R1b is CN; R1d is C1-4haloalkyl or C1-4haloalkoxy; and R1a, R1c and R1e are H; (e) R1b is C1-4haloalkyl or C1-4haloalkoxy; and R1a, R1c and R1e are H; and R1d is H or CN; (f) R1a is halogen; R1c is halogen, CN, C1-4alkyl, C1-4haloalkyl or C1-4haloalkoxy; and R1b, R1d and R1e are H; (g) R1c is halogen, CN, C1-4haloalkyl or C1-4haloalkoxy; and R1a, R1b and R1e are H; and R1d is halogen, CN, C1-4haloalkoxy, or H; R2 is selected from H, C1-4alkyl and halogen; R2a, R2b, R2c, R3, R4a, R4b, R4c, R4d, R5a, R5b, R5c, R6a, R6b, R6c, R6d, R6e, R6f, R6g, R6h, R6i, R6j, R6k and R6l are independently selected from H and C1-4alkyl.
|
