Use of complement inhibitors to treat ocular diseases

摘要

The present invention relates to the treatment of ocular diseases and conditions by administering a complement pathway inhibitor, particularly an alternative pathway inhibitor. Ocular diseases include age-related macular degeneration, diabetic retinopathy, and ocular angiogenesis. One embodiment comprises the administration of an anti-Factor D antibody in the form of a whole antibody, a Fab fragment or a single domain antibody. Other complement component inhibitors that may be useful in the present method include Factor H or inhibitors that block the action of properdin, factor B, factor Ba, factor Bb, C2, C2a, C3a, C5, C5a, C5b, C6, C7, C8, C9, or C5b-9.

主权项

1. A method for ameliorating macular degeneration, comprising administering an effective amount of a complement inhibitor to a subject in need thereof, wherein the complement inhibitor is an antibody or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment specifically binds to Factor D.