Enhancing vessel lesion homing and repair potential of stem cells

摘要

Disclosed herein are methods of enhancing repair of vascular lesions involving the administration of cells in which TGF-β expression and/or activity has been transiently blocked. Other methods involve the administration of a TGF-β blocking agent to a subject who has a vascular lesion or is at risk of developing a vascular lesion. Alternatively, a TGF-β blocking agent and treated cells are co-administered to a subject in need thereof.

主权项

1. A method of treating vascular lesions in a subject in need thereof, said method comprising
procuring CD34+ stem cells from said subject to obtain procured hematopoietic stem cells; treating said procured CD34+ stem cells, ex vivo, by blocking activity of TGF-β1 in said stem cells to obtain treated CD34+ stem cells; administering said treated hematopoietic stem cells to said subject wherein said treated hematopoietic stem cells home to the vascular lesions in the subject, wherein said treated hematopoietic stem cells comprise enhanced homing ability compared to the hematopoietic stem cells at the procuring step.