| 摘要 |
A dicarba analogue of insulin comprising an A-chain and a B-chain or fragments, salts, solvates, derivatives, isomers or tautomers of the A-chain, the B-chain or both, provided that the dicarba analogue is not [A7,B7-(2,7-diaminosuberoyl]-des-(B26-B30)-insulin B25-amide. |
| 主权项 |
1. A dicarba analogue of insulin comprising (1) an A-chain or a fragment, salt, solvate, derivative, isomer, or tautomer of the A-chain and (2) a B-chain or a fragment, salt, solvate, derivative, isomer, or tautomer of the B-chain and one or more intrachain dicarba bridges located on the A chain, the B chain or both, provided that the dicarba analogue is not [A7, B7-(2,7-diaminosuberoyl]-des-(B26-B30)-insulin B25-amide.
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