| 摘要 |
Provided is a pharmaceutical composition for the treatment and prevention of cardiac diseases, containing (a) a therapeutically effective amount of a compound represented by Formula 1 or 2 or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, and (b) a pharmaceutically acceptable carrier, diluent or excipient or any combination thereof. |
| 主权项 |
1. A method of treating and preventing cardiac diseases, comprising:
administering to a patient in need thereof, a pharmaceutical composition comprising:
(a) a therapeutically effective amount of one or more selected from compounds represented by Formulae 1 and 2: or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof; and (b) a pharmaceutically acceptable carrier, diluent or excipient or any combination thereof: wherein:
R1 and R2 are each independently hydrogen, halogen, hydroxyl, or C1-C6 lower alkyl or alkoxy, or R1 and R2 may be taken together to form a substituted or unsubstituted cyclic structure which may be saturated or partially or completely unsaturated;R3, R4, R5, R6, R7 and R8 are each independently hydrogen, hydroxyl, C1-C20 alkyl, alkene or alkoxy, or C4-C20 cycloalkyl, heterocycloalkyl, aryl or heteroaryl, or two of R3 to R8 may be taken together to form a cyclic structure which may be saturated or partially or completely unsaturated;X is selected from the group consisting of C(R)(R′), N(R″) wherein R, R′ and R″ are each independently hydrogen or C1-C6 lower alkyl, O and S;Y is C, S or N, with the proviso that R7 and R8 are absent when Y is S, and R7 is hydrogen or C1-C6 lower alkyl and R8 is absent when Y is N;n is 0 or 1, with the proviso that when n is 0, carbon atoms adjacent to n form a cyclic structure via a direct bond; andwherein the cardiac disease is selected from the group consisting of heart hypertrophy, heart failure, congestive heart failure, and angina pectoris.
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