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1. A composition comprising:
a) adipose tissue; b) a silk fibroin material; and c) a therapeutically effective amount of a compound of the structure of formula I wherein each dashed line represents the presence or absence of a bond; R1, R2 and R3 are each independently selected from H or C1-6 alkyl;
R6 is CO2H, CO2R7, CON(R7)2, CONHCH2CH2OH, CON(CH2CH2OH)2, CH2OR7, P(O)(OR7)2, R7 is independently H, C1-C6 alkyl or C2-C6 alkenyl;X and Y are each independently selected from H, OH, ═O, Cl, Br, I, or CF3;Z1 and Z2 are each independently selected from CH or N;W1 and W2 are each independently selected from CH, CH2, optionally substituted aryl, or optionally substituted heteroaryl;m is 0, 1, 2, 3, 4, 5 or 6;o is 0, 1, 2, 3, or 4;p is 0 or 1; andV is methyl, optionally substituted aryl, or optionally substituted heteroaryl; wherein, when V is methyl, Z1 or Z2 is N; a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable amine salt thereof.
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