| 发明名称 |
Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity |
| 摘要 |
The present invention generally relates to inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt), in particularly to compounds that inhibit Icmt activity and pharmaceutical compositions thereof. The invention also relates to methods of disease treatment using the same. |
| 申请公布号 |
US8742100(B2) |
申请公布日期 |
2014.06.03 |
| 申请号 |
US201013388050 |
申请日期 |
2010.07.30 |
| 申请人 |
National University of Singapore |
发明人 |
Leow Jo Lene;Casey Mei-Wang;Casey Patrick J.;Go Mei Lin;Suresh Kumar Gorla |
| 分类号 |
C07D209/14;C07D401/06;C07D403/06;C07D413/06 |
主分类号 |
C07D209/14 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A compound of Formula Ior a pharmaceutically acceptable salt thereof,wherein
R1 is (CH3)m-aryl, wherein m is 1; Y is hydrogen; R2 is C1-20alkyl; R3 is selected from the group consisting of CH2NH2, CH2N(CH3)2, CH2N(C2H5)2, CH2N(C3H7)2, R4 is hydrogen or C1-C4 alkyl.
|
| 地址 |
Singapore SG |
