Chimeric vaccine for <i>Haemophilus influenzae</i>-induced disease

摘要

The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein and methods of eliciting an immune response using the recombinant chimeric proteins of the invention.

主权项

1. A method for eliciting an immune response to NTHi bacteria comprising administering an immunogenic dose of a chimeric protein to a patient at risk of NTHi bacterial infection wherein the chimeric protein comprises i) an immunogenic PilA peptide selected from the group consisting of the amino acid sequence of SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8 or residues 40 to 149 of SEQ ID NO: 2 and ii) the LB 1 peptide selected from the group consisting of the amino acid sequence of SEQ ID NO: 4 and SEQ ID NO: 5, wherein the LB 1 peptide is inserted before the immunogenic PilA peptide.