发明名称 |
Monoclonal antibody against oxidized low-density lipoprotein |
摘要 |
Provided is a monoclonal antibody against slightly oxidized LDL, which can play a role as an important tool in the research and development of oxidized LDL. Also provided are a kit for the simple detection of slightly oxidized LDL and a method for the simple detection of slightly oxidized LDL from the biological sample of a subject to be tested which use the monoclonal antibody. By means of ELISA (Enzyme-Linked Immunosorbent Assay) using the monoclonal antibody as the solid phase antibody and an anti-apolipoprotein B antibody as the detection antibody, the degree of reaction between a severely oxidized low-density lipoprotein and the monoclonal antibody is low in comparison to the degree of reaction between a slightly oxidized low-density lipoprotein and the monoclonal antibody, and the monoclonal antibody specifically reacts with an oxidized low-density lipoprotein. |
申请公布号 |
US8729240(B2) |
申请公布日期 |
2014.05.20 |
申请号 |
US201113695043 |
申请日期 |
2011.04.28 |
申请人 |
CHIBA HITOSHI;KOBAYASHI SEIICHI;FURUKAWA HIROYUKI;NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY |
发明人 |
CHIBA HITOSHI;KOBAYASHI SEIICHI;FURUKAWA HIROYUKI |
分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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