METHOD FOR POSITIONING AN ATOMIC FORCE MICROSCOPY TIP IN A CELL
摘要
<p>A method for positioning a tip of an atomic force microscope relative to a intracellular target site in a cell is provided. In general terms, the method comprises: a) positioning a fluorescent tip of an atomic force microscope over a cell comprising a fluorescent intracellular target site so that said tip is above target site; b) moving the tip toward said target site while obtaining images of the distal end of said tip and/or the target site using a fluorescence microscope; and c) arresting the movement of the tip when the target site and the distal end of the tip are both in focus in the fluorescence microscope. A microscope system for performing the method is also provided.</p>
申请公布号
EP2729817(A1)
申请公布日期
2014.05.14
申请号
EP20120808208
申请日期
2012.07.03
申请人
AGILENT TECHNOLOGIES, INC.
发明人
YAMADA, NAZUMI ALICE;CURRY, BO U.;RANKL, CHRISTIAN