发明名称 |
APTAMERS AND USES THEREOF |
摘要 |
Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as micro vesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods. |
申请公布号 |
CA2928520(A1) |
申请公布日期 |
2014.05.08 |
申请号 |
CA20132928520 |
申请日期 |
2013.10.23 |
申请人 |
CARIS LIFE SCIENCES SWITZERLAND HOLDINGS, S.A.R.L. |
发明人 |
HALBERT, DAVID;DOMENYUK, VALERIY;SPETZLER, DAVID;HORNUNG, TASSILO;SCHAFER, FRANK;XIAO, NICK |
分类号 |
C12N15/115;C12Q1/68 |
主分类号 |
C12N15/115 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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