DOWNREGULATION OF INFLAMMATORY MICRORNAS BY ILT3

摘要

It has been discovered that inhibition of two or more specific inflammatory miRs (30b, 21, 146a, and 155) suppresses T cell proliferation, promotes T cell anergy or induces the formation of suppressor T cells, thereby providing a focused therapy with minimal toxicity for disorders associated with abnormally high immune responses. The corollary involves increasing the level of certain proinflammatory miRs thereby providing methods for immuno stimulation. It has also been discovered that significant increases of serum miR21 which occur in heart allograft rejection can be used to identify patients that have this disorder without requiring a biopsy.