LIVE ATTENUATED METABOLIC DRIFT VACCINE AGAINST FOWL TYPHOID

摘要

The present invention relates to the development of a new live fowl typhoid (FT) vaccine candidate against Salmonella Gallinarum (SG), with two independent attenuating mutations based on metabolic drift (MD), spontaneous chromosomal mutations. Such vaccine candidate fulfills the security demand of the World Health Organization (WHO). The vaccine proved to be genetically stable, safe and effective in experimental studies. This attenuated vaccine strain is designed sufficiently invasive to induce immunity in poultry, in particular chickens, and the vaccinated animals were protected against experimental SG challenge. The vaccine can be used for chicken and can be administered orally which is an easy and cost effective alternative to injection.