发明名称 |
INDIVIDUALIZED IMMUNOMODULATION THERAPY FOR NEURODEGENERATIVE DISORDERS, CNS INJURY AND AGE-RELATED DEMENTIA |
摘要 |
A method for treating a disease, disorder, condition or injury of the Central Nervous System (CNS) in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of an active ingredient, such as a non-encephalitogenic or weakly encephalitogenic combination of a Th1 adjuvant and a CNS-specific antigen, causing activation of the choroid plexus of said subject and maintaining said activation by reducing immunosuppression and establishing Th1-type immune response at the choroid plexus thus allowing either anti-inflammatory immune cells or immune cells which acquire a healing phenotype at the cerebrospinal fluid to pass through the choroid plexus, and accumulate at a site of damage in the CNS caused by said disease, disorder, condition or injury is provided. |
申请公布号 |
WO2014037952(A1) |
申请公布日期 |
2014.03.13 |
申请号 |
WO2013IL50761 |
申请日期 |
2013.09.10 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD AT THE WEIZMANN INSTITUTE OF SCIENCE |
发明人 |
EISENBACH-SCHWARTZ, MICHAL;FRIEDMAN, NIR;BARUCH, KUTI;KUNIS, GILAD;CAHALON, LIORA;ROSENZWEIG, NETA;DECZKOWSKA, ALEKSANDRA |
分类号 |
A01N63/00;A61K38/00;G01N33/00 |
主分类号 |
A01N63/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|