| 摘要 |
<p>The present invention provides a compound of formula (I):
wherein ring B is substituted or unsubstituted carbocycle or heterocycle,
R 1 is substituted or unsubstituted alkyl or the like,
R 2a and R 2b are each independently hydrogen, substituted or unsubstituted alkyl or the like,
R 3 , R 4a and R 4b are each independently hydrogen, halogen, substituted or unsubstituted alkyl or the like, a dashed line represents a presence or absence of a bond,
R 5 is hydrogen, substituted or unsubstituted alkyl or the like,
R 6 is halogen, hydroxy, substituted or unsubstituted alkyl or the like,
p is an integer of 0 to 3,
or a pharmaceutically acceptable salt thereof which has an effect of inhibiting amyloid ² production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ² proteins.</p> |
