Provided are benzocyclooctyne compounds of formula (I). These compounds undergo strain-promoted azide-alkyne cyclo additions (SPAAC) without presence of toxic metal catalysts. The provided compounds are useful for diagnosis and imaging of azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.
申请公布号
CA2883168(A1)
申请公布日期
2014.02.27
申请号
CA20132883168
申请日期
2013.08.21
申请人
ACADEMIA SINICA;WONG, CHI-HUEY;FANG, JIM-MIN;SHIE, JIUN-JIE