| 发明名称 |
2,4,5-TRIPHENYL IMIDAZOLINE DERIVATIVES AS INHIBITORS OF THE INTERACTION BETWEEN P53 AND MDM2 PROTEINS FOR USE AS ANTICANCER AGENTS |
| 摘要 |
There is provided a compound of formula (I) and the pharmaceutically acceptable salts and esters thereof wherein X1 , X2, R1 , R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents. |
| 申请公布号 |
CA2630410(C) |
申请公布日期 |
2014.02.25 |
| 申请号 |
CA20062630410 |
申请日期 |
2006.11.22 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
DING, QINGJIE;GRAVES, BRADFORD JAMES;KONG, NORMAN;LIU, JIN-JUN;LOVEY, ALLEN JOHN;PIZZOLATO, GIACOMO;ROBERTS, JOHN LAWSON;SO, SUNG-SAU;VU, BINH THANH;WOVKULICH, PETER MICHAEL |
| 分类号 |
C07D233/22;A61K31/4164;A61K31/496;A61P35/00;C07D233/26;C07D401/06;C07D403/06;C07D407/12;C07D409/12;C07D471/04;C07D487/04 |
主分类号 |
C07D233/22 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
