Tumor targeted drug Combretastatin A4 derivative

摘要

The present invention relates to a group of A-ring 4-position substituted 3,5-dimethoxy phenyl imidazole, oxazole and thiazole tumor targeted drug Combretastatin A4 derivatives, the phosphoric acid ester and sulphonic acid ester thereof, or the pharmaceutically acceptable salt, glycoside derivatives and solvolyte thereof. A pharmacological activity screening test shows that a compound has better exosomatic antitumor activity and good microtubulin inhibition effect.