发明名称 |
PYRIMIDINE COMPOUNDS INHIBITING THE FORMATION OF NITRIC OXIDE AND PROSTAGLANDIN E2, METHOD OF PRODUCTION THEREOF AND USE THEREOF |
摘要 |
<p>The invention provides pyrimidine compounds of general formula (I), which reduce simultaneously the production of nitric oxide (NO) and prostaglandin E2 (PGE2). They have no negative effect on the viability of cells in concentrations decreasing the production of these factors by up to 50%; they are not cytotoxic. Furthermore, a method of preparation of the pyrimidine compounds of general formula (I), carrying 2-formamido group, a pharmaceutical composition comprising the substituted pyrimidine compounds according to the invention, and the use of these compounds for the treatment of inflammatory and cancer diseases are provided.</p> |
申请公布号 |
EP2680847(A1) |
申请公布日期 |
2014.01.08 |
申请号 |
EP20120710650 |
申请日期 |
2012.02.27 |
申请人 |
USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CR, V.V.I.;USTAV EXPERIMENTALNI MEDICINY AKADEMIE VED CR, V.V.I. |
发明人 |
JANSA, PETR;HOLY, ANTONIN;ZIDEK, ZDENEK;KMONICKOVA, EVA;JANEBA, ZLATKO |
分类号 |
A61K31/505;A61K31/506;A61P29/00;A61P35/00;A61P37/00;C07D239/20;C07D239/34;C07D239/36;C07D239/38;C07D239/42;C07D401/04;C07D403/04;C07D405/04;C07D409/04 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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