发明名称 |
Compositions Comprising a Taxane for Coating Medical Devices |
摘要 |
The present invention relates a pharmaceutical composition comprising a taxane and an inhibitory compound capable of inhibiting the enzyme acetaldehyde dehydrogenase e.g. disulfiram. The pharmaceutical compositions of the invention can be used to coat medical devices such as implants. Such implant can be an expansible hollow part, having at least one opening, which consists of an elastic biocompatible material that comprises elongated micro-cavities in its surface. Medical devices coated with a pharmaceutical composition of the invention exhibit an enhanced transfer of taxane from the surface of said medical device into the target tissue. |
申请公布号 |
US2013345296(A1) |
申请公布日期 |
2013.12.26 |
申请号 |
US201113819538 |
申请日期 |
2011.08.31 |
申请人 |
HEILMANN TORSTEN;NOACK HEIKO;RICHTER CHRISTIAN;POST SABINE;AVIDAL VASCULAR GMBH |
发明人 |
HEILMANN TORSTEN;NOACK HEIKO;RICHTER CHRISTIAN;POST SABINE |
分类号 |
A61K31/337;A61K31/198;A61K31/27 |
主分类号 |
A61K31/337 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|