发明名称 |
OLIGONUCLEOTIDE-CONTAINING MICROSPHERES, THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING DIABETES TYPE 1 |
摘要 |
<p>AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.</p> |
申请公布号 |
PT1758558(E) |
申请公布日期 |
2013.12.05 |
申请号 |
PT20050749674T |
申请日期 |
2005.05.12 |
申请人 |
BAXTER HEALTHCARE S.A.;BAXTER INTERNATIONAL INC.;UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
TERRENCE L. SCOTT;DEBORAH LAFRENIERE;NICK GIANNOUKAKIS;VERED BISKER-LIEB;LARRY L. BROWN;JENNIFER MACHEN |
分类号 |
A61K9/16;A61K9/00;A61K9/19;C12N15/11;C12N15/113 |
主分类号 |
A61K9/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|