发明名称 |
EFFICIENT PRODUCTION OF HETEROLOGOUS PROTEINS USING MANNOSYL TRANSFERASE INHIBITORS |
摘要 |
Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidinediones inhibitors of Pmt-mediated O-linked glycosylation.
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申请公布号 |
US2013316398(A1) |
申请公布日期 |
2013.11.28 |
申请号 |
US201213588022 |
申请日期 |
2012.08.17 |
申请人 |
DESAI RANJIT;YANG LIHU;MERCK SHARPE & DOHME CORP. |
发明人 |
DESAI RANJIT;YANG LIHU |
分类号 |
C12P21/00;C07D277/36 |
主分类号 |
C12P21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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