IMPROVED PREPARATION OF OXYMORPHONE FROM ORIPAVINE
摘要
<p>An improved method for the preparation of oxymorphone from oripavine is provided. Oripavine is oxidized to form 14-hydroxymorphinone after which the oxidation reaction is quenched to prevent the formation of 1-1′-dimer side products. The 14-hydroxymorphinone is then reduced, typically by catalytic hydrogenation to form oxymorphone. The inventive method disclosed is further applicable to the production of morphinan derivatives.</p>
申请公布号
EP2125824(B1)
申请公布日期
2013.11.20
申请号
EP20080732176
申请日期
2008.03.14
申请人
MALLINCKRODT LLC
发明人
WANG, PETER, X.;JIANG, TAO;CANTRELL, GARY, L.;BERBERICH, DAVID, WAYNE