发明名称 |
SURFACE ANCHORED LIGHT CHAIN BAIT ANTIBODY DISPLAY SYSTEM |
摘要 |
The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of using the system for identifying antibodies that bind specifically to an antigen of interest. |
申请公布号 |
WO2013169609(A1) |
申请公布日期 |
2013.11.14 |
申请号 |
WO2013US39609 |
申请日期 |
2013.05.06 |
申请人 |
MERCK SHARP & DOHME CORP.;SHAHEEN, HUSSAM HASHAM;ZHA, DONGXING |
发明人 |
SHAHEEN, HUSSAM HASHAM;ZHA, DONGXING |
分类号 |
C40B30/04 |
主分类号 |
C40B30/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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