PROCESS FOR PREPARING HEXAMETHYLENEBISCYANOGUANIDINE AND CHLORHEXIDINE

摘要

The present invention is directed to a process for preparing hexamethylenebiscyanoguanidine. This compound is used as an intermediate to prepare chlorhexidine. The formation of the hexamethylenebiscyanoguanidine proceeds under base catalysis in an organic solvent. The base used in accordance with the invention is chlorhexidine itself. In addition, this invention enables the preparation of chlorhexidine base in a so-called one-pot process without intermediate isolation of the HMBCG.