发明名称 |
MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS |
摘要 |
<p>Mathematical models for the analysis of signal data generated by sequencing of a polynucleotide strand using a pH-based method of detecting nucleotide incorporation(s). In an embodiment, the measured output signal from the reaction confinement region of a reactor array is mathematically modeled. The output signal may be modeled as a linear combination of one or more signal components, including a background signal component. This model is solved to determine the nucleotide incorporation signal. In another embodiment, the incorporation signal from the reaction confinement region of a reactor array is mathematically modeled.</p> |
申请公布号 |
EP2658999(A2) |
申请公布日期 |
2013.11.06 |
申请号 |
EP20110811287 |
申请日期 |
2011.12.29 |
申请人 |
LIFE TECHNOLOGIES CORPORATION |
发明人 |
REARICK, TODD;SCHULTZ, JONATHAN |
分类号 |
C12Q1/68;C40B30/00;G06F17/10 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|