发明名称 |
METHOD FOR INCREASING NEPRILYSIN EXPRESSION AND ACTIVITY |
摘要 |
<p>This invention is directed to methods and compositions for increasing the expression or activity of neprilysin in, for example, the frontal cortex or the entorhinal cortex using a progranulin polypeptide or effector. The present invention is further directed to methods of reducing microglia in the brain of a patient with neurodegenerative disease using a progranulin polypeptide or effector.</p> |
申请公布号 |
EP2640407(A1) |
申请公布日期 |
2013.09.25 |
申请号 |
EP20110842037 |
申请日期 |
2011.11.16 |
申请人 |
KAY, DENIS G.;VAN KAMPEN, JACKALINA M. |
发明人 |
KAY, DENIS G.;VAN KAMPEN, JACKALINA M. |
分类号 |
A61K38/17;A61K38/18;A61P25/00;A61P25/28;C07K14/475 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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