SINGLE-STRANDED NUCLEIC ACID MOLECULE FOR INHIBITING VEGF GENE EXPRESSION

摘要

Provided is a new nucleic acid molecule that inhibits the activity of TLR 3 and the expression of the VEGF gene. The single-stranded nucleic acid molecule for inhibiting the expression of the VEGF gene is characterized in that: a 5'-side region (Xc), an internal region (Z) and a 3'-side region (Yc) are included, in that order, from the 5' side to the 3' side; the internal region (Z) is formed by linking an internal 5'-side region (X) and an internal 3'-side region (Y); the 5'-side region (Xc) is complementary to the internal 5'-side region (X); the 3'-side region (Yc) is complementary to the internal 3'-side region (Y); and at least one region among the internal region (Z), the 5'-side region and the 3'-side region includes an expression-inhibiting sequence that inhibits the expression of the VEGF gene. The single-stranded nucleic acid molecule is capable of inhibiting the activity of TLR 3 and the expression of the VEGF gene.