发明名称 |
ANTAGONIST FOR MUTATED ANDROGEN RECEPTOR |
摘要 |
<p>[Problem] An object of the present invention is to provide a novel anticancer drug which is useful for treating prostate cancer accompanying androgen receptor mutation [Means for Solution] The present inventors conducted thorough research on mutant androgen-related diseases for which the traditional anti-androgen drugs become ineffective. As a result, they found that the compound, which is an active ingredient of the pharmaceutical composition of the present invention, exhibits an inhibitory action against transcriptional activation in a human mutant androgen receptor (AR), and has an excellent antitumor action in a human prostate cancer-bearing mouse, thereby completing the present invention. Accordingly, the compound, which is an active ingredient of the pharmaceutical composition of the present invention, is useful for a series of androgen receptor-related diseases including prostate cancer.</p> |
申请公布号 |
EP2631233(A1) |
申请公布日期 |
2013.08.28 |
申请号 |
EP20110834469 |
申请日期 |
2011.10.21 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
IDEYAMA, YUKITAKA;KUROMITSU, SADAO;FURUTANI, TAKASHI;TAKEDA, MASAYOSHI;KONAGAI, SATOSHI;YAMADA, TOMOHIRO;TANIGUCHI, NOBUAKI;KONDOH, YUTAKA;HIRANO, MASAAKI;WATANABE, KAZUSHI;SUGANE, TAKASHI;KAKEFUDA, AKIO |
分类号 |
C07D401/12;A61K31/496;A61K31/506;A61P5/26;A61P35/00;C07D403/12 |
主分类号 |
C07D401/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|